Produce your sample in yeast
Yeasts has many of the advantages of higher eukaryotic expression systems such as protein processing, protein folding and post-translational modification. Protocols for isotopic labelling are well described and give high incorporation rates. We have a project to develop efficient methyl specific isotopic labelling in yeast (Pichia pastoris) in 2020.
If you are interested, please contact us at: email@example.com to set up a collaborative project together.